Not on my 2005 Gulfstream as it has the main and auxiliary, gas up both tanks. Be sure to switch tanks before either tank runs completely out, if not you must remove filters and refill as bulbs will not refill filters.
May or may not be the case with your problem but if you run out of gas on either tank it will suck all fuel from filters etc. and neither will run until you change tanks and refill filters. If not, call seatow or U.S. don’t ask how I know!