At 5000 lbs dry, your performance might be close to this:
http://www.evinrude.com/Content/Pdf/neu ... /PE628.pdf
(The hulls are different but that is the heaviest boat they list with a single 300.)
Did your whole transom get replaced? Any photos? That transom was rated for 400HP so it should handle the 300 assuming it was rebuilt properly. If you are uncomfortable with the E-Tec's torque, you could just go easy on the throttle. That's what I do with my twins. Speaking of torque, with one engine out of the water I was able to hit 35 MPH on a single 200HO. I've posted that before, you can see it here if your are interested:
http://www.youtube.com/watch?v=0PffCDl8WNM
I went easy on the throttle there because it didn't want to beat on the motor any more than necessary - they are 2006's.
See if the Evinrude dealer will throw in or give you a break on an I-command or Icon gauges. Your old gauges will work but it is nice to be able to monitor all the information the digital gauges can handle these days. I'm planning to replace my old tachs with I-Command tachs after the boat show.
I also like twins because of the maneuverability at the docks and the redundancy but I suspect you will burn a lot less gas than I and others do with twin 225s, regardless of the number of strokes.