On the coast in New England we keep our boat on a mooring, so "flush every use" was a question I put to my local Yamaha expert. His perspective was that "flush every use" is an ideal circumstance and is typical of a corporate owner's manual language. There's a ton of experience and history of the F225 documented on the web, and overall the priority as I read it is
1) more engine use is better than less use which is better than intermittent use, which is better than neglect, and
2) some flushing is better than no flushing.
So with our 282, I try to flush any opportunity that I get time on the dock when the motors are already warmed up. It ends up being at least once or twice a month, and my mechanic didn't express any particular concern with that, provided that some flushing is happening, and we're also keeping up with the power head anodes.
If you do review the manual for flushing procedure, it does specifically state "not while running" and that the motors should be partially tilted up during flush using the fitting on the cowling. So I definitely don't flush while they're running.
This is an opinion piece, your mileage may vary (wait, my mileage may vary!)
Bob.