We have a 95 w / 200hp mercs that will need replacing at some point. We'll go with another set of 200 hp 2 stroke. If for no other reason they are all ~100# lighter than 4 stokes. Not as fuel efficient, by we don't venture too far from home. Also heard of the added weight of 4strokes lowering the transom somewhat on a boat that already has a tendency to squat while getting on plane. If we go 4 strike, we'd definitely get 225 hp, while 200 is plenty for the lighter 2strokes.
With our old 200 mercs we cruise at 3500rpm/25kt top out at 5200rpm /38 it. Plenty fast.
Not sure but I think the 2strokes are several thousand less per engine. That's about 700 gal of fuel, with oil to go with it. Based on fuel efficiency, it would take us several years to recoup the added cost for four strokes.